|
KMID : 1101420180500030331
|
|
Korean Journal of Clinical Laboratory Science
2018 Volume.50 No. 3 p.331 ~ p.336
|
|
|
Genetic Variations of Candida albicans Isolated from Clinical Specimens Using Multi-locus Sequence Typing Analysis
|
|
Kim Hee-Jin
Kim Sang-Ha
Kim Sung-Hyun
Yu Young-Bin
Kim Young-Kwon
|
|
|
Abstract
|
|
|
|
In this study, multi-locus sequence typing (MLST) analysis of 40 clinically isolated Candida albicans in tertiary hospitals in Daejeon, Korea, confirmed the nucleotide sequence and phylogenetic relationships of the strains collected from different specimen sources. The general variations found in seven different housekeeping genes of C. albicans, collected from urine and sputum, peripheral blood, central line blood, and other specimens, were analyzed. The phylogenetic tree was divided into 18 sub-clusters (1), a central line blood (2), others (5), sputum (1), peripheral blood (6), sputum (1), and urine (1), and the isolates at the same site were confirmed to have genetic similarity. Consequently, genetic similarity and the potential relevance were found in the strains collected from the same specimen sources. MLST analysis of C. albicans suggests that persistent data accumulation of phylogenetic gene variations of C. albicans may help establish infectious disease studies and epidemiological surveillance systems.
|
|
|
KEYWORD
|
|
|
Clinical specimens, Candida albicans, Genetic variation, MLST analysis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|